Publications

2022

2021

  • Pulmonary hypertension in bronchopulmonary dysplasia. Hansmann G, Sallmon H, Roehr CC, Kourembanas S, Austin ED, Koestenberger M; European Pediatric Pulmonary Vascular Disease Network (EPPVDN).Pediatr Res. 2021 Feb;89(3):446-455. doi: 10.1038/s41390-020-0993-4. Epub 2020 Jun 10.PMID: 32521539 Review.

 

2020

  • Meinel K, Koestenberger M, Sallmon H, Hansmann G, Pieles GE. Echocardiography for the Assessment of Pulmonary Hypertension and Congenital Heart Disease in the Young. Diagnostics (Basel). 2020 Dec 31;11(1):49. doi: 10.3390/diagnostics11010049.PMID: 33396225 Review. | Pubmed
  • Toshner M, Spiekerkoetter E, Bogaard H, Hansmann G, Nikkho S, Prins KW. Repurposing of medications for pulmonary arterial hypertension.Pulm Circ. 2020 Nov 18;10(4):2045894020941494. doi: 10.1177/2045894020941494. eCollection 2020 Oct Dec.PMID: 33282182 Review. | Pubmed
  • Hamrick SEG, Sallmon H, Rose AT, Porras D, Shelton EL, Reese J, Hansmann G. Patent Ductus Arteriosus of the Preterm Infant. Pediatrics. 2020 Nov;146(5):e20201209. doi: 10.1542/peds.2020-1209.PMID: 33093140 Review. | Pubmed
  • Klinke A, Schubert T, Müller M, Legchenko E, Zelt JGE, Shimauchi T, Napp LC, Rothman AMK, Bonnet S, Stewart DJ, Hansmann G, Rudolph V. Emerging therapies for right ventricular dysfunction and failure. Cardiovasc Diagn Ther. 2020 Oct;10(5):1735-1767.doi: 10.21037/cdt-20-592.PMID: 33224787 Review. | Pubmed
  • Hansmann G, Rich S, Maron BA. Cardiac catheterization in pulmonary hypertension: doing it right, with a catheter on the left.Cardiovasc Diagn Ther. 2020 Oct;10(5):1718-1724. doi: 10.21037/cdt-20-483.PMID: 33224785. | Pubmed
  • Sallmon H, Berger F, Weber SC, Fischer HS, Hansmann G, Opgen-Rhein B. Interventional creation of an endogenous reverse Potts shunt in an infant with pulmonary hypertension and genetic surfactant disorder-a case report.Cardiovasc Diagn Ther. 2020 Oct;10(5):1696-1700. doi: 10.21037/cdt.2020.03.11.PMID: 33224783 | Pubmed
  • Giagnorio R, Hansmann G. Mineralocorticoid receptor blockade improves pulmonary hypertension and right ventricular function in bronchopulmonary dysplasia: a case report.Cardiovasc Diagn Ther. 2020 Oct;10(5):1686-1690. doi: 10.21037/cdt.2020.02.05.PMID: 33224781 | Pubmed
  • Schweintzger S, Koestenberger M, Schlagenhauf A, Grangl G, Burmas A, Kurath-Koller S, Pocivalnik M, Sallmon H, Baumgartner D, Hansmann G, Gamillscheg A. Safety and efficacy of the endothelin receptor antagonist macitentan in pediatric pulmonary hypertension.Cardiovasc Diagn Ther. 2020 Oct;10(5):1675-1685. doi: 10.21037/cdt.2020.04.01.PMID: 33224780 | Pubmed
  • Inampudi C, Tedford RJ, Hemnes AR, Hansmann G, Bogaard HJ, Koestenberger M, Lang IM, Brittain EL. Treatment of right ventricular dysfunction and heart failure in pulmonary arterial hypertension.Cardiovasc Diagn Ther. 2020 Oct;10(5):1659-1674. doi: 10.21037/cdt-20-348.PMID: 33224779 Review | Pubmed
  • Santens B, Van De Bruaene A, De Meester P, D’Alto M, Reddy S, Bernstein D, Koestenberger M, Hansmann G, Budts W. Diagnosis and treatment of right ventricular dysfunction in congenital heart disease.Cardiovasc Diagn Ther. 2020 Oct;10(5):1625-1645. doi: 10.21037/cdt-20-370.PMID: 33224777 Review. | Pubmed
  • Bernardo RJ, Haddad F, Couture EJ, Hansmann G, de Jesus Perez VA, Denault AY, de Man FS, Amsallem M. Mechanics of right ventricular dysfunction in pulmonary arterial hypertension and heart failure with preserved ejection fraction.Cardiovasc Diagn Ther. 2020 Oct;10(5):1580-1603. doi: 10.21037/cdt-20-479.PMID: 33224775 Review. | Pubmed
  • Andersen A, van der Feen DE, Andersen S, Schultz JG, Hansmann G, Bogaard HJ. Animal models of right heart failure.Cardiovasc Diagn Ther. 2020 Oct;10(5):1561-1579.doi: 10.21037/cdt-20-400.PMID: 33224774 Review | Pubmed.
  • Agrawal V, Lahm T, Hansmann G, Hemnes AR. Molecular mechanisms of right ventricular dysfunction in pulmonary arterial hypertension: focus on the coronary vasculature, sex hormones, and glucose/lipid metabolism.Cardiovasc Diagn Ther. 2020 Oct;10(5):1522-1540. doi: 10.21037/cdt-20-404.PMID: 33224772 Review. | Pubmed
  • Koestenberger M, Bogaard HJ, Hansmann G. Getting to the bottom of right heart failure.Cardiovasc Diagn Ther. 2020 Oct;10(5):1517-1521. doi: 10.21037/cdt-20-565.PMID: 33224771 | Pubmed
  • Hansmann G, Bezzerides V. Paediatric/congenital cardiology physician scientists-An endangered species. Eur J Clin Invest. 2020 Oct;50(10):e13367. doi: 10.1111/eci.13367. Epub 2020 Sep 5.PMID: 32735699 | Pubmed
  • Chouvarine P, Giera M, Kastenmüller G, Artati A, Adamski J, Bertram H, Hansmann G. Trans-right ventricle and transpulmonary metabolite gradients in human pulmonary arterial hypertensionHeart. 2020 Sep;106(17):1332-1341. doi: 10.1136/heartjnl-2019-315900. Epub 2020 Feb 20.PMID: 32079620 | Pubmed.
  • Koestenberger M, Avian A, Chouvarine P, Gamillscheg A, Cvirn G, Schweintzger S, Kurath-Koller S, Cantinotti M, Hohmann D, Hansmann G. Right ventricular end-systolic remodeling index in the assessment of pediatric pulmonary arterial hypertension. The European Pediatric Pulmonary Vascular Disease Network (EPPVDN).Pediatr Res. 2020 Aug;88(2):285-292. doi: 10.1038/s41390-020-0748-2. Epub 2020 Jan 10.PMID: 31923914 | Pubmed
  • Hansmann G, Meinel K, Bukova M, Chouvarine P, Wåhlander H, Koestenberger M; European Pediatric Pulmonary Vascular Disease Network (EPPVDN).Selexipag for the treatment of children with pulmonary arterial hypertension: First multicenter experience in drug safety and efficacy. J Heart Lung Transplant. 2020 Jul;39(7):695-706. doi: 10.1016/j.healun.2020.03.029. Epub 2020 Apr 7.PMID: 32362477 | Pubmed
  • Sallmon H, Metze B, Koehne P, Opgen-Rhein B, Weiss K, Will JC, Franke CV, Hansmann G, Koestenberger M, Bührer C, Berger F, Weber SC, Cremer M. Mature and immature platelets during the first week after birth and incidence of patent ductus arteriosus. Cardiol Young. 2020 Jun;30(6):769-773. doi: 10.1017/S1047951120000943. Epub 2020 Apr 28.PMID: 32340633 | Pubmed
  • Hasan B, Hansmann G, Budts W, Heath A, Hoodbhoy Z, Jing ZC, Koestenberger M, Meinel K, Mocumbi AO, Radchenko GD, Sallmon H, Sliwa K, Kumar RK; European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, CSC, PASCAR, PCS, and PCSI. Challenges and Special Aspects of Pulmonary Hypertension in Middle- to Low-Income Regions: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020 May 19;75(19):2463-2477. doi: 10.1016/j.jacc.2020.03.047.PMID: 32408981 Review. | Pubmed
  • Kaemmerer H, Gorenflo M, Huscher D, Pittrow D, Apitz C, Baumgartner H, Berger F, Bruch L, Brunnemer E, Budts W, Claussen M, Coghlan G, Dähnert I, D’Alto M, Delcroix M, Distler O, Dittrich S, Dumitrescu D, Ewert R, Faehling M, Germund I, Ghofrani HA, Grohé C, Grossekreymborg K, Halank M, Hansmann G, Harzheim D, Nemes A, Havasi K, Held M, Hoeper MM, Hofbeck M, Hohenfrost-Schmidt W, Jurevičienė E, Gumbienè L, Kabitz HJ, Klose H, Köhler T, Konstantinides S, Köestenberger M, Kozlik-Feldmann R, Kramer HH, Kropf-Sanchen C, Lammers A, Lange T, Meyn P, Miera O, Milger-Kneidinger K, Neidenbach R, Neurohr C, Opitz C, Perings C, Remppis BA, Riemekasten G, Scelsi L, Scholtz W, Simkova I, Skowasch D, Skride A, Stähler G, Stiller B, Tsangaris I, Vizza CD, Vonk Noordegraaf A, Wilkens H, Wirtz H, Diller GP, Grünig E, Rosenkranz S. Pulmonary Hypertension in Adults with Congenital Heart Disease: Real-World Data from the International COMPERA-CHD Registry.J Clin Med. 2020 May 13;9(5):1456. doi: 10.3390/jcm9051456.PMID: 32414075 | Pubmed.
  • Koestenberger M, Hansmann G.Left Ventricular Geometry and Near-Simultaneous Invasive Hemodynamics in Pediatric Pulmonary Hypertension. Circ Cardiovasc Imaging. 2020 May;13(5):e010787. doi: 10.1161/CIRCIMAGING.120.010787. Epub 2020 May 15.PMID: 32408826 | Pumed
  • Koestenberger M, Avian A, Cantinotti M, Meinel K, Hansmann G. A novel echocardiographic approach indicates disease severity in pediatric pulmonary hypertension.Pediatr Int. 2020 May;62(5):637-639. doi: 10.1111/ped.14163. Epub 2020 Apr 17.PMID: 32304149 | Pubmed
  • Köhler D, Granja T, Volz J, Koeppen M, Langer HF, Hansmann G, Legchenko E, Geisler T, Bakchoul T, Eggstein C, Häberle HA, Nieswandt B, Rosenberger P. Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb. Nat Commun. 2020 Mar 11;11(1):1315. doi: 10.1038/s41467-020-14958-x.PMID: 32161256 | Pubmed
  • Kökény G, Calvier L, Legchenko E, Chouvarine P, Mózes MM, Hansmann G. PPARγ is a gatekeeper for extracellular matrix and vascular cell homeostasis: beneficial role in pulmonary hypertension and renal/cardiac/pulmonary fibrosis. Curr Opin Nephrol Hypertens. 2020 Mar;29(2):171-179 doi: 10.1097/MNH.0000000000000580.PMID: 31815758 Review. | Pubmed
  • Bogaard HJ, Legchenko E, Ackermann M, Kühnel MP, Jonigk DD, Chaudhary KR, Sun X, Stewart DJ, Hansmann G. The Adult Sprague-Dawley Sugen-Hypoxia Rat Is Still “the One:” A Model of Group 1 Pulmonary Hypertension: Reply to Le Cras and Abman. Am J Respir Crit Care Med. 2020 Mar 1;201(5):621-624. doi: 10.1164/rccm.201910-1983LE.PMID: 31769697 | Pubmed
  • Hansmann G, Calvier L, Risbano MG, Chan SY. Activation of the Metabolic Master Regulator PPARγ: A Potential PIOneering Therapy for Pulmonary Arterial Hypertension. Am J Respir Cell Mol Biol. 2020 Feb;62(2):143-156. doi: 10.1165/rcmb.2019-0226PS.PMID: 31577451 Review. | Pubmed
  • Köhler D, Granja T, Volz J, Koeppen M, Langer HF, Hansmann G, Legchenko E, Geisler T, Eggstein C, Häberle HA, Nieswandt B, Rosenberger P. Red Blood Cell (RBC)–derived Semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through a platelet GPIb-dependent mechanism. Nature Communications 2020, in press
  • Chouvarine P, Giera M, Kastenmüller G, Artati A, Adamski J, Bertram H, Hansmann G. Trans-Right-Ventricle and Transpulmonary Metabolite Gradients in Human Pulmonary Arterial Hypertension. Heart 2020; 2020 Feb 20:heartjnl-2019-315900. doi: 10.1136/heartjnl-2019-315900. Online ahead of print.Pubmed Free article.
  • Koestenberger M, Avian A, Chouvarine P, Gamillscheg A, Cvirn G, Schweintzger S, Kurath-Koller S, Cantinotti M, Hohmann D, Hansmann G. Right Ventricular End-Systolic Remodeling Index in the Assessment of Pediatric Pulmonary Arterial Hypertension. The European Pediatric Pulmonary Vascular Disease Network (EPPVDN). Ped Res 2020, doi: 10.1038/s41390-020-0748-2. Pubmed
  • Trans-Right-Ventricle and Transpulmonary MicroRNA Gradients in Human Pulmonary Arterial Hypertension.
    Chouvarine P, Geldner J, Giagnorio R, Legchenko E, Bertram H, Hansmann G. Pediatr Crit Care Med. 2020 Apr;21(4):340-349. doi: 10.1097/PCC.0000000000002207.
    Pubmed

2019

Original Articles

  • Calvier L, Boucher P, Herz J, Hansmann G. LRP1 deficiency in vascular SMC leads to pulmonary arterial hypertension that is reversed by PPARγ activation. Circulation Research. 2019; 124: 1778-1785; doi: 10.1161/CIRCRESAHA.119.315088 Pubmed
  • Koestenberger M, Avian A, Cantinotti M, Hansmann G; European Pediatric Pulmonary Vascular Disease Network. Tricuspid annular plane systolic excursion (TAPSE) in pediatric pulmonary hypertension: Integrating right ventricular ejection efficiency (RVEe) into advanced multi-parametric imaging. Int J Cardiol. 2019; 274:296-298. doi: 10.1016/j.ijcard.2018.07.013 Pubmed
  • Koestenberger M, Sallmon H, Avian A, Cantinotti M, Gamillscheg A, Kurath-Koller S, Schweintzger S, Hansmann G. Ventricular-ventricular interaction variables correlate with surrogate variables of clinical outcome in children with pulmonary hypertension. Pulm Circ. 2019; 9(2):2045894019854074. doi: 10.1177/2045894019854074. Pubmed
  • Chouvarine P, Geldner J, Giagnorio R, Legchenko E, Bertram H, Hansmann G. Trans-Right-Ventricle and Transpulmonary MicroRNA Gradients in Human Pulmonary Arterial Hypertension. Pediatr Crit Care Med 2019; in press doi: 10.1097/PCC.0000000000002207 Pubmed
  • Chouvarine P, Legchenko E, Geldner J, Riehle C, Hansmann G. Hypoxia drives cardiac miRNAs and inflammation in the right and left ventricle. J Mol Med. 2019; 97: 1427-1438. doi: 10.1007/s00109-019-01817-6 Pubmed
  • Calvier L, Chouvarine P, Legchenko E, Kokeny G, Mozes MM, Hansmann G. Chronic TGF-β1 signaling in pulmonary arterial hypertension induces sustained canonical Smad3 pathways in vascular smooth muscle cells. Am J Resp Cell Mol Biol. 2019; 61: 121-123. doi: 10.1165/rcmb.2018-0275LE Pubmed
  • Nemeth, A, Mozes MM, Calvier L, Hansmann G, Kokeny G. The PPARγ agonist pioglitazone prevents TGF-β induced renal fibrosis by repressing EGR-1 and STAT3. BMC Nephrol. 2019; 20: 245. doi: 10.1186/s12882-019-1431-x Pubmed
  • Bogaard HJ, Legchenko E, Chaudhary KR, Sun X, Stewart DJ, Hansmann G.  Emphysema is – at the most – only a Mild Phenotype in the Sugen-Hypoxia Rat Model of Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2019; doi: 10.1164/rccm.201906-1200LE. Pubmed
  • Bogaard HJ, Legchenko E, Ackerman M, Kühnel MP, Jonigk DD, Chaudhary KR, Sun X, Stewart DJ, Hansmann G. The Adult Sprague-Dawley Sugen-Hypoxia Rat Is Still “The One:” A Model of Group 1 Pulmonary Hypertension: Reply to Le Cras and Abman. Am J Respir Crit Care Med. 2019; doi: 10.1164/rccm.201910-1983LE Pubmed

Clinical Guidelines, Consensus Statements

  • Hansmann G (chair), Koestenberger M (co-chair), Alastalo T, Apitz C, Austin E, Bonnet D, Budts W, D’Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh RMR, Warnecke G, Wåhlander H, Weber SC and Zartner P. 2019 Updated Consensus Statement on the Diagnosis and Treatment of Pediatric Pulmonary Hypertension. The European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, ESPR and ISHLT. J Heart Lung Transplant. 2019; DOI: https://doi.org/10.1016/j.healun.2019.06.022 Pubmed
  • Sallmon H, Moledina S, Albert DC, Beghetti M, Berger RMF, Bonnet D, Bukova M, Koestenberger M, Meinel K, Reinhardt Z, Tulloh RMR, de Wolf D, Hansmann G. Recommendations from the Association for European Paediatric and Congenital Cardiology for training in pulmonary hypertension. Cardiol Young. 2019; 26: 1-5. doi: 10.1017/S104795111900235X. Pubmed

Reviews

  • Kökény G, Calvier L, Legchenko E, Chouvarine P, Mózes MM, Hansmann G. PPARγ Is a Gatekeeper for Extracellular Matrix and Vascular Cell Homeostasis: Beneficial Role in Pulmonary Hypertension and Renal/Cardiac/Pulmonary Fibrosis. 2019; Curr Opin Nephrol Hypertens. doi: 10.1097/MNH.0000000000000580 Pubmed

Perspectives

  • Koestenberger M, Sallmon H, Hansmann G; European Pediatric Pulmonary Vascular Disease Network. A pediatric perspective on the TAPSE/PASP ratio in pulmonary arterial hypertension. Int J Cardiol. 2019 Mar 1;278:242. doi:  10.1016/j.ijcard.2018.11.092.4 Pubmed
  • Hansmann G, Calvier L, Risbano MG, Chan SY. Activation of The Metabolic Master Regulator PPARγ – A Potential PIOneering Therapy for Pulmonary Arterial Hypertension. Am J RespirCell Mol Biol. 2019 Oct 2. doi:  10.1165/rcmb.2019-0226PS. Perspective Article. Pubmed

2018

Original Articles

  • Legchenko E, Chouvarine P, Borchert P, Fernandez-Gonzalez A, Snay E, Meier M, Maegel L, Mitsialis SA, Rog-Zielinska E, Kourembanas S, Jonigk D, Hansmann G. The PPARgamma agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure through fatty acid oxidation. Science Translational Medicine. 2018; doi: 10.1126/scitranslmed.aao0303 PDF | Pubmed
  • Schlegel M, Körner, M, Kaussen T, Knausberg U, Gerber C, Hansmann G, Jónasdóttir HS, Giera M, Mirakaj V. Inhibition of neogenin fosters resolution of inflammation and tissue regeneration. Journal of Clinical Investigation 2018; 128:4711-4726. Pubmed
  • Koestenberger M, Avian A, Sallmon H, Gamillscheg A, Grangl G, Kurath-Koller S, Schweintzger S, Burmas A, Hansmann G. The right ventricular outflow tract in pediatric pulmonary hypertension—Data from the European Pediatric Pulmonary Vascular Disease Network. Echocardiography 2018; doi: 10.1111/echo.13852 Pubmed
  • Koestenberger M, Avian A, Gamillscheg A, Sallmon H, Grangl G, Burmas A, Schweintzger S, Kurath-Koller S, Cvirn G, Hansmann G. Right Ventricular Base/Apex Ratio in the Assessment of Pediatric Pulmonary Arterial Hypertension – Results from the European Pediatric Pulmonary Vascular Disease Network. Clin Cardiol 2018. doi: 10.1002/clc.22994 Pubmed
  • Sallmon H, Weber SC, Dirks J, Schiffer T, Klippstein T, Stein A, Felderhoff-Müser U, Metze B, Hansmann G, Bührer C, Cremer M, Koehne P. Association between platelet counts before and during pharmacological therapy for patent ductus arteriosus and treatment failure in preterm infants. Front. Pediatr 2018, https://doi.org/10.3389/fped.2018.00041Pubmed
  • Koestenberger M, Avian A, Cantinotti M, Hansmann G; European Pediatric Pulmonary Vascular Disease Network. Tricuspid annular plane systolic excursion (TAPSE) in pediatric pulmonary hypertension: Integrating right ventricular ejection efficiency (RVEe) into advanced multi-parametric imaging. Int J Cardiol. 2019 Jan 1;274:296-298. doi: 10.1016/j.ijcard.2018.07.013. Epub 2018 Jul 3. Pubmed

Consensus Statements and Guidelines

  • Reinhardt Z, Hansmann G, O’Sullivan J, Murtuza B, Köstenberger M, Schranz D, Bonnet D, Burch M. Recommendations from the Association for European Paediatric and Congenital     Cardiology for clinical training in paediatric heart failure and transplantation. Cardiol Young. 2018 Sep 12:1-4. doi: 10.1017/S1047951118001221. Pubmed
  • Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kuebler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT. Pathobiology, pathology and genetics of pulmonary hypertension: Update from the Cologne Consensus Conference 2018. Int J Cardiol. 2018 Sep 20. pii: S0167-5273(18)35661-4. doi: 10.1016/j.ijcard.2018.09.070. Pubmed

Case Reports (peer reviewed)

  • Spreemann T, Bertram H, Happel C, Kozlik-Feldmann R, Hansmann G. First-in-Child Use of the Oral Soluble Guanylate Cyclase Stimulator Riociguat in Pulmonary Arterial Hypertension. Pulm Circ 2018 Jan-Mar;8(1) doi: 10.1177/2045893217743123 Pubmed
  • Sallmon H, Berger F, Koehne P, Koestenberger M, Hansmann G, Opgen-Rhein B. Different indications for transcatheter and surgical patent ductus arteriosus closure in preterm infants less than 2kg. Int J Cardiol. 2018 Sep 1;266:83. doi: 10.1016/j.ijcard.2017.11.029. Pubmed

Perspectives, Editorials, Letters

  • Koestenberger M, Hansmann G. Should we use the oral selective IP receptor agonist selexipag off-label in children with pulmonary arterial hypertension? Pulm Circ. 2018 Jul-Sep;8(3):2045894018793580. doi: 10.1177/2045894018793580. Pubmed
  • Koestenberger M, Avian A, Meinel K, Sallmon H, Hansmann G; European Pediatric Pulmonary Vascular Disease Network. Reply to “Diagnostic and prognostic value of echocardiography in pulmonary arterial hypertension”. Clin Cardiol. 2018 Sep;41(9):1152-1153. doi: 10.1002/clc.23038. Pubmed

2017

  • Calvier L, Chouvarine P, Legchenko E, Hoffmann N, Geldner J, Borchert P, Jonigk D,  Mozes MM, Hansmann G . PPARγ links BMP2 and TGFβ1 pathways in vascular smooth muscle cells, regulating cell proliferation and glucose metabolism. Cell Metabolism. 2017 May 2;25(5):1118-1134.e7. doi: 10.1016/j.cmet.2017.03.011. PDF | Pubmed
  • Sallmon H, Hatch A, Plouffe BD, Murthy SK, Hansmann G (2017). Circulating endothelial cell quantification by microfluidics-chip in pulmonary arterial hypertension. Am J Respir Cell Mol Biol. 2017 May;56(5):680-682. doi: 10.1165/rcmb.2017-0026LE. PDF | Pubmed
  • Koestenberger M, Grangl G, Avian A, Gamillscheg A, Grillitsch M, Cvirn G, Burmas A, Hansmann G. Normal reference values and z-scores of the pulmonary artery acceleration time (PAAT) in children and its importance for the assessment of pulmonary hypertension. Circulation Cardiovascular Imaging. 2017 Jan;10(1). pii: e005336. doi: 10.1161/CIRCIMAGING.116.005336. PDF | Pubmed

Editorial, Clinical and Translational Reviews

  • Hansmann G. Pulmonary hypertension in infants, children and young adults. J Am Coll Cardiol. 2017;69:2551–69 PDF | Pubmed | Audio
  • Koestenberger M, Hansmann G, Apitz C, Latus H, Lammers A. Diagnostics in Children and Adolescents with Suspected or Confirmed Pulmonary Hypertension. Paediatr Respir Rev. 2017 Jun;23:3-15. doi: 10.1016/j.prrv.2016.10.006 Pubmed
  • Koestenberger M, Sallmon H, Hansmann G (2017). The Selective Prostacyclin (Ip) Receptor Agonist Selexipag: A Promising Drug in Pediatric Pulmonary Artery Hypertension. J Intensive & Crit Care. Vol.3 No.4:42.

Case Reports (peer reviewed)

  • Geerdink LM, Bertram H, Hansmann G. First-in-child use of the oral selective prostacyclin IP receptor agonist selexipag in pulmonary arterial hypertension. Pulm Circ. 2017 Apr-Jun;7(2):551-554 Epub 2017 May 12. Pubmed
  • Spreemann T, Bertram H, Happel C, Kozlik-Feldmann R, Hansmann G. EXPRESS: First-in-Child Use of the Oral Soluble Guanylate Cyclase Stimulator Riociguat in Pulmonary Arterial Hypertension. Pulm Circ 2018 Jan-Mar;8(1): EPub . 2017 Nov 3 doi: 10.1177/2045893217743123 Pubmed

2016

  • Koestenberger M, Burmas A, Ravekes W, Avian A, Gamillscheg A, Grangl G, Grillitsch M, Hansmann G. Echocardiographic Reference Values for Right Atrial Size in Children with and without Atrial Septal Defects or Pulmonary Hypertension. Pediatr Cardiol. 2016 Apr;37(4):686-95 Pubmed
  • Koestenberger M, Avian A, Grangl G, Burmas A, Kurath-Koller S, Hansmann G. Right ventricular outflow tract velocity time integral (RVOT VTI) and tricuspid regurgitation velocity/RVOT VTI ratio in pediatric pulmonary hypertension. Int J Cardiol. 2016 Jun 1;212:274-6. Pubmed
  • Hansmann G (chair), Apitz C (co-chair), Abdul-Khaliq H, Alastalo TP, Beerbaum P, Bonnet D, Dubowy KO, Gorenflo M, Hager A, Hilgendorff A, Michel-Behnke I, Miera O, Kaestner M, Koestenberger M, Koskenvuo JW, Kozlik-Feldmann R, Kuehne T, Lammers A, Latus H, Moledina S, Muthurangu V, Pattathu J, Schranz D, Warnecke G, Zartner P. Executive summary. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii86-ii100. doi: 10.1136/heartjnl-2015-309132. Pubmed
  • Hansmann G, Apitz C. Treatment of children with pulmonary hypertension. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii67-ii85. doi: 10.1136/heartjnl-2015-309103. Pubmed
  • Latus H, Kuehne T, Beerbaum P, Apitz C, Hansmann G, Muthurangu V, Moledina, S. Cardiac MR and CT imaging in children with suspected or confirmed pulmonary hypertension/pulmonary hypertensive vascular disease. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii30-ii35. doi: 10.1136/heartjnl-2015-308246. Pubmed
  • Hilgendorff A,  Apitz C, Bonnet D, Hansmann G. Pulmonary hypertension associated with acute or chronic lung diseases in the preterm and term neonate and infant. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK.  Heart. 2016 May;102 Suppl 2:ii49-ii56. doi: 10.1136/heartjnl-2015-308591. Pubmed
  • Kozlik-Feldmann R, Hansmann G, Bonnet D, Schranz D, Apitz C, Michel-Behnke I. Pulmonary hypertension in children with congenital heart disease (PAH-CHD, PPHVD-CHD). Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii42-ii48. doi: 10.1136/heartjnl-2015-308378.Pubmed
  • Lammers A, Apitz C, Zartner P, Hager A, Dubowy KO, Hansmann G. Diagnostics, monitoring and outpatient care in children with suspected pulmonary hypertension/paediatric pulmonary hypertensive vascular disease. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii1-ii13. doi: 10.1136/heartjnl-2015-307792. Pubmed
  • Kaestner M, Schranz D, Warnecke G, Apitz C, Hansmann G, Miera O. Pulmonary hypertension in the intensive care unit. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii57-ii66. doi: 10.1136/heartjnl-2015-307774. Pubmed
  • Koestenberger M, Apitz C, Abdul-Khaliq H, Hansmann G. Transthoracic echocardiography for the evaluation of children and adolescents with suspected or confirmed pulmonary hypertension. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and D6PK. Heart. 2016 May;102 Suppl 2:ii14-ii22. doi: 10.1136/heartjnl-2014-307200. Pubmed
  • Apitz C, Hansmann G, Schranz D. Hemodynamic assessment and acute pulmonary vasoreactivity testing in the evaluation of children with pulmonary vascular disease. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii23-ii29. doi: 10.1136/heartjnl-2014-307340. Pubmed
  • Pattathu J, Gorenflo M, Hilgendorff M, Koskenvuo KW, Apitz C, Hansmann G, Alastalo TP. Genetic testing and blood biomarkers in paediatric pulmonary hypertension. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii36-ii41. doi: 10.1136/heartjnl-2014-307238. Pubmed
  • Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M, Aboyans V, Vaz Carneiro A, Achenbach S, Agewall S, Allanore Y, Asteggiano R, Paolo Badano L, Albert Barberà J, Bouvaist H, Bueno H, Byrne RA, Carerj S, Castro G, Erol Ç, Falk V, Funck-Brentano C, Gorenflo M, Granton J, Iung B, Kiely DG, Kirchhof P, Kjellstrom B, Landmesser U, Lekakis J, Lionis C, Lip GY, Orfanos SE, Park MH, Piepoli MF, Ponikowski P, Revel MP, Rigau D, Rosenkranz S, Völler H, Luis Zamorano. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). European Heart Journal  2016 Jan 1;37(1):67-119 PDF | Pubmed
  • Calvier L*, Legchenko E*, Grimm L*, Sallmon H, Hatch A, Plouffe BD, Schroeder C, Bauersachs J, Murthy SK, Hansmann G. (2016) Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertension. *shared first author Heart 2016;102:390-396 doi:10.1136/heartjnl-2015-308365 PDF | Pubmed See Heartbeat by C. Otto, Heart, March 2016 See editorial by B. Maron, Heart, March 2016

Editorial, Clinical and Translational Reviews

  • Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kübler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT. Pathobiology, pathology and genetics of pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016. Deutsche Medizinische Wochenschrift 2016; 141: 4-9
  • Koestenberger M, Hansmann G, Apitz C, Latus H, Lammers A.Diagnostics in Children and Adolescents with Suspected or Confirmed Pulmonary Hypertension. Paediatr Respir Rev. 2016 Oct 26. pii: S1526-0542(16)30120-8. doi: 10.1016/j.prrv.2016.10.006. [Epub ahead of print]
  • Hansmann G. Left Ventricular Diastolic Dysfunction in Pediatric Pulmonary Hypertension. Circulation: Cardiovascular Imaging. 2016; 9: e005527. doi: 10.1161/CIRCIMAGING.116.005527 PDF| Link
  • Koestenberger M, Friedberg MK, Nestaas E, Michel-Behnke I, Hansmann G. Transthoracic echocardiography in the evaluation of pediatric pulmonary hypertension and ventricular dysfunction. Pulmonary Circulation. 2016 Mar;6(1):15-29. doi: 10.1086/685051. Pubmed
  • Sallmon H, Koehne P, Hansmann G. Recent Advances in the Treatment of Preterm Newborn Infants with Patent Ductus Arteriosus. Clin Perinatol. 2016 Mar;43(1):113-29. doi: 10.1016/j.clp.2015.11.008. Pubmed

2015

  • Koestenberger M, Burmas A, Ravekes W, Avian A, Gamillscheg A, Grangl G, Grillitsch M, Hansmann G Echocardiographic Reference Values for Right Atrial Size in Children with and without Atrial Septal Defects or Pulmonary Hypertension. Pediatric Cardiology 2015 Dec 26 Pubmed
  • Galiè N, Humbert M, Vachiéry JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M. 2015 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J 2015; 46: 903-75 doi: 10.1183/13993003.01032-2015. Pubmed
  • Weber SC, Weiss K, Buhrer C, Hansmann G, Koehne P, Sallmon H (2015). Natural history of patent ductus arteriosus in VLBW infants after discharge. Journal of Pediatrics Pubmed
  • Abman SA (co-chair*), Hansmann G (co-chair*), Archer SL (co-chair*), Ivy DD, Adatia I, Chung  WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M,  Barst RJ, Keller RL, MD, Kinsella JP, Mullen M, Deterding R,  Kulik T, Mallory G, Humpl T, Wessel DL AHA/ATS joint guidelines on pediatric pulmonary hypertension (2015). Circulation,2015;132:2037-2099. DOI: 10.1161/CIR.0000000000000329 Pubmed

2014

  • Sallmon H, Barikbin P, Koehne P, von Gise A, Hansmann G (2014). Platelet-rich plasma for the treatment of patent ductus arteriosus: not quite ready for prime time. Cardiol Young. 2014 Aug 27:1-2. [Epub ahead of print]. Pubmed
  • Vitali SH#, Hansmann G#, Rose C, Fernandez-Gonzalez A, Scheid A, Kourembanas S (2014). The Sugen (SU5416) hypoxia mouse model of pulmonary hypertension revisited: long-term follow-up. #Both authors contributed equally to this work. Pulmonary Circulation 2014 Dec;4(4):619-29. doi: 10.1086/678508 Pubmed

2013

  • Hansmann G (2013). Interdisciplinary networks for the treatment of childhood pulmonary vascular disease – what PH doctors can learn from pediatric oncologists. Pulmonary Circulation in press (perspective) PDF | Pubmed
  • Hansmann G, Hoeper MM (2013). Registries for paediatric pulmonary hypertension. European Respiratory Journal 2013 Sep;42(3):580-3. doi: 10.1183/09031936.00065713 PDF | Pubmed
  • von Gise A, Archer SL, MacLean MR, Hansmann G. Full conference report: The first Keystone Symposia Conference on pulmonary vascular disease and right ventricular dysfunction – Current concepts and future therapies Pulmonary Circulation 2013;3:0 DOI: 10.4103/2045-8932.114786 PDF
  • von Gise A, Archer SL, MacLean MR, Hansmann G. The first Keystone Symposia conference on pulmonary vascular disease and right ventricular dysfunction: current concepts and future therapies. Pulmonary Circulation (editorial) 2013;3:275-7 DOI: 10.4103/2045-8932.114751 PDF | Pubmed

2012

  • Hansmann G#,Fernandez-Gonzalez A#, Aslam M, Vitali SH, Martin T, Mitsialis, SA, Kourembanas S. Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension. #Both authors contributed equally to this work. Pulmonary Circulation 2012; 2: 170-181 PDF | Pubmed
  • Sallmon H*, Weber SD*, Hüning B, Stein A, Horn P, Dame C, Bührer C, Felderhoff-Müser U, Hansmann G# **, Koehne P**. Thrombocytopenia in the first 24 hours after birth and Incidence of PDA in VLBW infants. #GH is corresponding author. *, ** Contributed equally as first* and senior** authors. Pediatrics 2012: 130:e623-630 PDF | Pubmed
  • Koestenberger M, Friedberg MK, Ravekes W, Nestaas E, Hansmann G (2012). Non-invasive imaging for congenital heart disease: recent innovations in transthoracic echocardiography. Journal of Clinical and Experimental Cardiology S8:002 doi:10.4172/2155-9880.S8-e002 PDF
  • Hansmann G, Sigler M (2012). Innovative approaches to congenital heart disease. Journal of Clinical and Experimental Cardiology (editorial). S8:001 doi:10.4172/2155-9880.S8-e001 PDF

2011

  • Hatch A, Hansmann G, Murthy SK. Engineered alginate hydrogels for effective microfluidic capture and release of endothelial progenitor cells from whole blood. Langmuir 2011;27: 4257-4264. International patent no. PCT/US12/23859, filed February 3, 2012 PDF | Pubmed
  • Hansmann G#, Plouffe BD#, Hatch A, von Gise A, Sallmon H, Zamanian RT and Murthy SK (2011). Design and validation of a novel endothelial progenitor cell (EPC) microfluidic capture chip and its application in patients with pulmonary arterial hypertension. #Both authors contributed equally to this work. Journal of Molecular Medicine 2011;89: 971-83. PDF | Pubmed

Editorial, Clinical and Translational Reviews

  • Sallmon H, Hansmann G: Neue Konzepte zur Behandlung der pulmonalarteriellen Hypertonie im Kindes- und Erwachsenenalter [New Therapeutic Concepts for children and adults with pulmonary arterial hypertension]. DIVI. 2011; 2: 106-111. invited review PDF
  • Roehr CC, Hansmann G, Hoehn T, Bührer C. The 2010 Guidelines on Neonatal Resuscitation (AHA, ERC, ILCOR): Similarities and Differences – What Progress Has Been Made since 2005? Klinische Pädiatrie 2011; 223: 299-307 invited review PDF | Pubmed

2010

  • De Felice C, Bechelli S, Tonni G, Latini G, Hansmann G. Systematic underestimation of oxygen delivery in ventilated preterm infants. Neonatology 2010; 98: 18-22 PDF| Pubmed
  • Hansmann G, Rabinovitch M. The protective role of adiponectin in pulmonary vascular disease. American Journal of Physiology – Lung Cellular and Molecular Physiology 2010; 298: L1-2. Epub 2009 Oct 30 (editorial) PDF | Pubmed

Editorial, Clinical and Translational Reviews

  • Hamrick SEG, Hansmann G. Patent ductus arteriosus of the preterm infant. Pediatrics 2010; 125: 1020-1030 PDF | Pubmed

2009

  • Hansmann G, Zamanian RT. PPARγ activation: a potential treatment for pulmonary hypertension. Science Translational Medicine 2009; 1: 12ps14 Epub 2009 Dec 23 PDF | Pubmed
  • Hansmann G#, Zamanian RT#, Snook S, Lilienfeld D, Rappaport K, Reaven G, Rabinovitch M, Doyle RL. Insulin resistance in pulmonary arterial hypertension. . #Contributed equally as first authors to this work. European Respiratory Journal 2009; 33: 318-324 PDF | Pubmed
  • Guignabert C, Alvira CM, Alastalo TP, Sawada H, Hansmann G, Zhao M, Wang L, El-Bizri N, Rabinovitch M. Tie2-mediated loss of peroxisome proliferator-activated receptor in mice causes PDGF-receptor ß-dependent pulmonary arterial muscularization. American Journal of Physiology – Lung Cellular and Molecular Physiology 2009; 297: L1082-1090 PDF | Pubmed

2008

  • Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, Bekkers J, Schellong S, Urashima T, Wang L, Morrell NW, Rabinovitch M. An antiproliferative BMP-2/ PPAR?/ApoE axis in human and murine SMCs and its role in pulmonary hypertension. Journal of Clinical Investigation 2008; 118: 1846-1857 PDF | Pubmed

Editorial, Clinical and Translational Reviews
>

  • Hoehn T, Hansmann G, Bührer C, Simbruner G, Gunn AJ, Yager J, Levene J, Hamrick SEG, Shankaran S, Thoresen M. Therapeutic hypothermia in neonates. Resuscitation 2008;78: 7-12 PDF | Pubmed

2007

  • Hansmann G, Wagner RA, Schellong S, de Jesus Perez VA, Urashima T, Wang L, Sheikh AY, Suen RS, Stewart DJ, Rabinovitch M. Pulmonary arterial hypertension is linked to insulin resistance and reversed by PPAR? activation. Circulation 2007; 115: 1275-1284 PDF | Pubmed

Editorial, Clinical and Translational Reviews

  • Hansmann G, Humpl T, Zimmermann A, Bührer C, Wauer RR, Stannigel H, Hoehn T. Neue Reanimationsrichtlinien der ILCOR bei Früh- und Reifgeborenen: Kritische Diskussion und Vorschläge zur praktischen Umsetzung [ILCOR’s new resuscitation guidelines in preterm and term infants: critical discussion and suggestions for implementation]. National Guidelines. Klinische Pädiatrie 2007;219: 50-57 Pubmed

1997-2006

  • Hansmann G. Neonatal resuscitation on air: it is time to turn down the oxygen tanks. Lancet 2004; 364: 1293-1294 (comment; erratum Lancet 2005; 365: 386) Pubmed
  • Hauck L, Hansmann G, Dietz R, von Harsdorf R. Inhibition of hypoxia-induced apoptosis by modulation of retinoblastoma protein-dependent signaling in cardiomyocytes. Circulation Research 2002; 91: 782-789 PDF | Pubmed
  • Hansmann G, Ihling C, Pieske B, Bültmann R. Nucleotide-evoked relaxation of human coronary artery. European Journal of Pharmacology 1998; 359: 59-67 PDF | Pubmed
  • Hansmann G, Bültmann R, Tuluc F, Starke K. Characterization by antagonists of P2-receptors mediating endothelium-dependent relaxation in the rat aorta. Naunyn-Schmiedeberg’s Archives of Pharmacology 1997; 356: 641-652 PDF | Pubmed
  • Bültmann R, Hansmann G, Tuluc F, Starke K. Vasoconstrictor and vasodilator effects of guanine nucleotides in the rat aorta. Naunyn-Schmiedeberg’s Archives of Pharmacology 1997; 356: 653-661 PDF | Pubmed

Letters to the editor

  • Gunn AJ, Hoehn T, Hansmann G, Bührer C, Simbruner G, Gunn AJ, Yager J, Levene J, Hamrick SEG, Shankaran S, Thoresen M. Hypothermia: an evolving treatment for neonatal hypoxic ischemic encephalopathy. Pediatrics 2008; 121: 648-649 PDF | Pubmed
  • Sallmon H, Weber SC, von Gise A, Koehne P, Hansmann G. Ductal closure in neonates – a developmental perspective on platetet-endothelial interactions. Blood Coagulation and Fibrinolysis 2011; 22: 242-244 PDF | Pubmed
  • Hansmann G, Haas F, Sadiq M, Brook M, Gildein HP. Arrival and survival of a 3 week old boy from Pakistan with an arterial oxygen saturation of 17%. British Medical Journal 2009 [doi:10.1136/bcr.07.2008.0500] PDF | Pubmed