Publications

2017

  • Calvier L, Chouvarine P, Legchenko E, Hoffmann N, Geldner J, Borchert P, Jonigk D,  Mozes MM, Hansmann G . PPARγ links BMP2 and TGFβ1 pathways in vascular smooth muscle cells, regulating cell proliferation and glucose metabolism. Cell Metabolism. 2017, in press
  • Sallmon H, Hatch A, Plouffe BD, Murthy SK, Hansmann G (2017). Circulating endothelial cell quantification by microfluidics-chip in pulmonary arterial hypertension. Am J Respir Cell Mol Biol. 2017, in press
  • Koestenberger M, Grangl G, Avian A, Gamillscheg A, Grillitsch M, Cvirn G, Burmas A, Hansmann G. Normal reference values and z-scores of the pulmonary artery acceleration time (PAAT) in children and its importance for the assessment of pulmonary hypertension. Circulation Cardiovascular Imaging. 2017 Jan;10(1). pii: e005336. doi: 10.1161/CIRCIMAGING.116.005336. PDF | Pubmed

Editorial, Clinical and Translational Reviews

  • Hansmann G. Pulmonary hypertension in infants, children and young adults. J Am Coll Cardiol. 2017;69:2551–69 PDF | Pubmed | Audio

2016

  • Koestenberger M, Burmas A, Ravekes W, Avian A, Gamillscheg A, Grangl G, Grillitsch M, Hansmann G. Echocardiographic Reference Values for Right Atrial Size in Children with and without Atrial Septal Defects or Pulmonary Hypertension. Pediatr Cardiol. 2016 Apr;37(4):686-95 Pubmed
  • Koestenberger M, Avian A, Grangl G, Burmas A, Kurath-Koller S, Hansmann G. Right ventricular outflow tract velocity time integral (RVOT VTI) and tricuspid regurgitation velocity/RVOT VTI ratio in pediatric pulmonary hypertension. Int J Cardiol. 2016 Jun 1;212:274-6. Pubmed
  • Hansmann G (chair), Apitz C (co-chair), Abdul-Khaliq H, Alastalo TP, Beerbaum P, Bonnet D, Dubowy KO, Gorenflo M, Hager A, Hilgendorff A, Michel-Behnke I, Miera O, Kaestner M, Koestenberger M, Koskenvuo JW, Kozlik-Feldmann R, Kuehne T, Lammers A, Latus H, Moledina S, Muthurangu V, Pattathu J, Schranz D, Warnecke G, Zartner P. Executive summary. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii86-ii100. doi: 10.1136/heartjnl-2015-309132. Pubmed
  • Hansmann G, Apitz C. Treatment of children with pulmonary hypertension. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii67-ii85. doi: 10.1136/heartjnl-2015-309103. Pubmed
  • Latus H, Kuehne T, Beerbaum P, Apitz C, Hansmann G, Muthurangu V, Moledina, S. Cardiac MR and CT imaging in children with suspected or confirmed pulmonary hypertension/pulmonary hypertensive vascular disease. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii30-ii35. doi: 10.1136/heartjnl-2015-308246. Pubmed
  • Hilgendorff A,  Apitz C, Bonnet D, Hansmann G. Pulmonary hypertension associated with acute or chronic lung diseases in the preterm and term neonate and infant. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK.  Heart. 2016 May;102 Suppl 2:ii49-ii56. doi: 10.1136/heartjnl-2015-308591. Pubmed
  • Kozlik-Feldmann R, Hansmann G, Bonnet D, Schranz D, Apitz C, Michel-Behnke I. Pulmonary hypertension in children with congenital heart disease (PAH-CHD, PPHVD-CHD). Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii42-ii48. doi: 10.1136/heartjnl-2015-308378.Pubmed
  • Lammers A, Apitz C, Zartner P, Hager A, Dubowy KO, Hansmann G. Diagnostics, monitoring and outpatient care in children with suspected pulmonary hypertension/paediatric pulmonary hypertensive vascular disease. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii1-ii13. doi: 10.1136/heartjnl-2015-307792. Pubmed
  • Kaestner M, Schranz D, Warnecke G, Apitz C, Hansmann G, Miera O. Pulmonary hypertension in the intensive care unit. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii57-ii66. doi: 10.1136/heartjnl-2015-307774. Pubmed
  • Koestenberger M, Apitz C, Abdul-Khaliq H, Hansmann G. Transthoracic echocardiography for the evaluation of children and adolescents with suspected or confirmed pulmonary hypertension. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and D6PK. Heart. 2016 May;102 Suppl 2:ii14-ii22. doi: 10.1136/heartjnl-2014-307200. Pubmed
  • Apitz C, Hansmann G, Schranz D. Hemodynamic assessment and acute pulmonary vasoreactivity testing in the evaluation of children with pulmonary vascular disease. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii23-ii29. doi: 10.1136/heartjnl-2014-307340. Pubmed
  • Pattathu J, Gorenflo M, Hilgendorff M, Koskenvuo KW, Apitz C, Hansmann G, Alastalo TP. Genetic testing and blood biomarkers in paediatric pulmonary hypertension. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016 May;102 Suppl 2:ii36-ii41. doi: 10.1136/heartjnl-2014-307238. Pubmed
  • Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M, Aboyans V, Vaz Carneiro A, Achenbach S, Agewall S, Allanore Y, Asteggiano R, Paolo Badano L, Albert Barberà J, Bouvaist H, Bueno H, Byrne RA, Carerj S, Castro G, Erol Ç, Falk V, Funck-Brentano C, Gorenflo M, Granton J, Iung B, Kiely DG, Kirchhof P, Kjellstrom B, Landmesser U, Lekakis J, Lionis C, Lip GY, Orfanos SE, Park MH, Piepoli MF, Ponikowski P, Revel MP, Rigau D, Rosenkranz S, Völler H, Luis Zamorano. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). European Heart Journal  2016 Jan 1;37(1):67-119 PDF | Pubmed
  • Calvier L*, Legchenko E*, Grimm L*, Sallmon H, Hatch A, Plouffe BD, Schroeder C, Bauersachs J, Murthy SK, Hansmann G. (2016) Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertension. *shared first author Heart 2016;102:390-396 doi:10.1136/heartjnl-2015-308365 PDF | Pubmed
    See Heartbeat by C. Otto, Heart, March 2016
    See editorial by B. Maron, Heart, March 2016

Editorial, Clinical and Translational Reviews

  • Koestenberger M, Hansmann G, Apitz C, Latus H, Lammers A.Diagnostics in Children and Adolescents with Suspected or Confirmed Pulmonary Hypertension. Paediatr Respir Rev. 2016 Oct 26. pii: S1526-0542(16)30120-8. doi: 10.1016/j.prrv.2016.10.006. [Epub ahead of print]
  • Hansmann G. Left Ventricular Diastolic Dysfunction in Pediatric Pulmonary Hypertension. Circulation: Cardiovascular Imaging. 2016; 9: e005527. doi: 10.1161/CIRCIMAGING.116.005527 PDF| Link
  • Koestenberger M, Friedberg MK, Nestaas E, Michel-Behnke I, Hansmann G. Transthoracic echocardiography in the evaluation of pediatric pulmonary hypertension and ventricular dysfunction. Pulm Circ. 2016 Mar;6(1):15-29. doi: 10.1086/685051. Pubmed
  • Sallmon H, Koehne P, Hansmann G. Recent Advances in the Treatment of Preterm Newborn Infants with Patent Ductus Arteriosus. Clin Perinatol. 2016 Mar;43(1):113-29. doi: 10.1016/j.clp.2015.11.008. Pubmed

2015

  • Koestenberger M, Burmas A, Ravekes W, Avian A, Gamillscheg A, Grangl G, Grillitsch M, Hansmann G Echocardiographic Reference Values for Right Atrial Size in Children with and without Atrial Septal Defects or Pulmonary Hypertension. Pediatric Cardiology 2015 Dec 26 Pubmed
  • Galiè N, Humbert M, Vachiéry JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M. 2015 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension.
    Eur Respir J 2015; 46: 903-75 doi: 10.1183/13993003.01032-2015. Pubmed
  • Weber SC, Weiss K, Buhrer C, Hansmann G, Koehne P, Sallmon H (2015). Natural history of patent ductus arteriosus in VLBW infants after discharge. Journal of Pediatrics Pubmed
  • Abman SA (co-chair*), Hansmann G (co-chair*), Archer SL (co-chair*), Ivy DD, Adatia I, Chung  WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M,  Barst RJ, Keller RL, MD, Kinsella JP, Mullen M, Deterding R,  Kulik T, Mallory G, Humpl T, Wessel DL AHA/ATS joint guidelines on pediatric pulmonary hypertension (2015). Circulation,2015;132:2037-2099. DOI: 10.1161/CIR.0000000000000329 Pubmed

2014

  • Sallmon H, Barikbin P, Koehne P, von Gise A, Hansmann G (2014). Platelet-rich plasma for the treatment of patent ductus arteriosus: not quite ready for prime time.
    Cardiol Young. 2014 Aug 27:1-2. [Epub ahead of print]. Pubmed
  • Vitali SH#, Hansmann G#, Rose C, Fernandez-Gonzalez A, Scheid A, Kourembanas S (2014). The Sugen (SU5416) hypoxia mouse model of pulmonary hypertension revisited: long-term follow-up. #Both authors contributed equally to this work. Pulmonary Circulation 2014 Dec;4(4):619-29. doi: 10.1086/678508 Pubmed

2013

  • Hansmann G (2013). Interdisciplinary networks for the treatment of childhood pulmonary vascular disease – what PH doctors can learn from pediatric oncologists. Pulmonary Circulation in press (perspective) PDF | Pubmed
  • Hansmann G, Hoeper MM (2013). Registries for paediatric pulmonary hypertension. European Respiratory Journal 2013 Sep;42(3):580-3. doi: 10.1183/09031936.00065713 PDF | Pubmed
  • von Gise A, Archer SL, MacLean MR, Hansmann G. Full conference report: The first Keystone Symposia Conference on pulmonary vascular disease and right ventricular dysfunction – Current concepts and future therapies Pulmonary Circulation 2013;3:0 DOI: 10.4103/2045-8932.114786 PDF
  • von Gise A, Archer SL, MacLean MR, Hansmann G. The first Keystone Symposia conference on pulmonary vascular disease and right ventricular dysfunction: current concepts and future therapies. Pulmonary Circulation (editorial) 2013;3:275-7 DOI: 10.4103/2045-8932.114751 PDF | Pubmed

2012

  • Hansmann G#,Fernandez-Gonzalez A#, Aslam M, Vitali SH, Martin T, Mitsialis, SA, Kourembanas S. Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension. #Both authors contributed equally to this work. Pulmonary Circulation 2012; 2: 170-181 PDF | Pubmed
  • Sallmon H*, Weber SD*, Hüning B, Stein A, Horn P, Dame C, Bührer C, Felderhoff-Müser U, Hansmann G# **, Koehne P**. Thrombocytopenia in the first 24 hours after birth and Incidence of PDA in VLBW infants. #GH is corresponding author. *, ** Contributed equally as first* and senior** authors. Pediatrics 2012: 130:e623-630 PDF | Pubmed
  • Koestenberger M, Friedberg MK, Ravekes W, Nestaas E, Hansmann G (2012). Non-invasive imaging for congenital heart disease: recent innovations in transthoracic echocardiography. Journal of Clinical and Experimental Cardiology S8:002 doi:10.4172/2155-9880.S8-e002 PDF
  • Hansmann G, Sigler M (2012). Innovative approaches to congenital heart disease. Journal of Clinical and Experimental Cardiology (editorial). S8:001 doi:10.4172/2155-9880.S8-e001 PDF

2011

  • Hatch A, Hansmann G, Murthy SK. Engineered alginate hydrogels for effective microfluidic capture and release of endothelial progenitor cells from whole blood. Langmuir 2011;27: 4257-4264. International patent no. PCT/US12/23859, filed February 3, 2012 PDF | Pubmed
  • Hansmann G#, Plouffe BD#, Hatch A, von Gise A, Sallmon H, Zamanian RT and Murthy SK (2011). Design and validation of a novel endothelial progenitor cell (EPC) microfluidic capture chip and its application in patients with pulmonary arterial hypertension. #Both authors contributed equally to this work. Journal of Molecular Medicine 2011;89: 971-83. PDF | Pubmed

Editorial, Clinical and Translational Reviews

  • Sallmon H, Hansmann G: Neue Konzepte zur Behandlung der pulmonalarteriellen Hypertonie im Kindes- und Erwachsenenalter [New Therapeutic Concepts for children and adults with pulmonary arterial hypertension]. DIVI. 2011; 2: 106-111. invited review PDF
  • Roehr CC, Hansmann G, Hoehn T, Bührer C. The 2010 Guidelines on Neonatal Resuscitation (AHA, ERC, ILCOR): Similarities and Differences – What Progress Has Been Made since 2005? Klinische Pädiatrie 2011; 223: 299-307 invited review PDF | Pubmed

2010

  • De Felice C, Bechelli S, Tonni G, Latini G, Hansmann G. Systematic underestimation of oxygen delivery in ventilated preterm infants. Neonatology 2010; 98: 18-22 PDF| Pubmed
  • Hansmann G, Rabinovitch M. The protective role of adiponectin in pulmonary vascular disease. American Journal of Physiology – Lung Cellular and Molecular Physiology 2010; 298: L1-2. Epub 2009 Oct 30 (editorial) PDF | Pubmed

Editorial, Clinical and Translational Reviews

  • Hamrick SEG, Hansmann G. Patent ductus arteriosus of the preterm infant. Pediatrics 2010; 125: 1020-1030 PDF | Pubmed

2009

  • Hansmann G, Zamanian RT. PPARγ activation: a potential treatment for pulmonary hypertension. Science Translational Medicine 2009; 1: 12ps14 Epub 2009 Dec 23 PDF | Pubmed
  • Hansmann G#, Zamanian RT#, Snook S, Lilienfeld D, Rappaport K, Reaven G, Rabinovitch M, Doyle RL. Insulin resistance in pulmonary arterial hypertension. . #Contributed equally as first authors to this work. European Respiratory Journal 2009; 33: 318-324 PDF | Pubmed
  • Guignabert C, Alvira CM, Alastalo TP, Sawada H, Hansmann G, Zhao M, Wang L, El-Bizri N, Rabinovitch M. Tie2-mediated loss of peroxisome proliferator-activated receptor in mice causes PDGF-receptor ß-dependent pulmonary arterial muscularization. American Journal of Physiology – Lung Cellular and Molecular Physiology 2009; 297: L1082-1090 PDF | Pubmed

2008

  • Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, Bekkers J, Schellong S, Urashima T, Wang L, Morrell NW, Rabinovitch M. An antiproliferative BMP-2/ PPAR?/ApoE axis in human and murine SMCs and its role in pulmonary hypertension. Journal of Clinical Investigation 2008; 118: 1846-1857 PDF | Pubmed

Editorial, Clinical and Translational Reviews

  • Hoehn T, Hansmann G, Bührer C, Simbruner G, Gunn AJ, Yager J, Levene J, Hamrick SEG, Shankaran S, Thoresen M. Therapeutic hypothermia in neonates. Resuscitation 2008;78: 7-12 PDF | Pubmed

2007

  • Hansmann G, Wagner RA, Schellong S, de Jesus Perez VA, Urashima T, Wang L, Sheikh AY, Suen RS, Stewart DJ, Rabinovitch M. Pulmonary arterial hypertension is linked to insulin resistance and reversed by PPAR? activation. Circulation 2007; 115: 1275-1284 PDF | Pubmed

Editorial, Clinical and Translational Reviews

  • Hansmann G, Humpl T, Zimmermann A, Bührer C, Wauer RR, Stannigel H, Hoehn T. Neue Reanimationsrichtlinien der ILCOR bei Früh- und Reifgeborenen: Kritische Diskussion und Vorschläge zur praktischen Umsetzung [ILCOR’s new resuscitation guidelines in preterm and term infants: critical discussion and suggestions for implementation]. National Guidelines. Klinische Pädiatrie 2007;219: 50-57 Pubmed

1997-2006

  • Hansmann G. Neonatal resuscitation on air: it is time to turn down the oxygen tanks. Lancet 2004; 364: 1293-1294 (comment; erratum Lancet 2005; 365: 386) Pubmed
  • Hauck L, Hansmann G, Dietz R, von Harsdorf R. Inhibition of hypoxia-induced apoptosis by modulation of retinoblastoma protein-dependent signaling in cardiomyocytes. Circulation Research 2002; 91: 782-789 PDF | Pubmed
  • Hansmann G, Ihling C, Pieske B, Bültmann R. Nucleotide-evoked relaxation of human coronary artery. European Journal of Pharmacology 1998; 359: 59-67 PDF | Pubmed
  • Hansmann G, Bültmann R, Tuluc F, Starke K. Characterization by antagonists of P2-receptors mediating endothelium-dependent relaxation in the rat aorta. Naunyn-Schmiedeberg’s Archives of Pharmacology 1997; 356: 641-652 PDF | Pubmed
  • Bültmann R, Hansmann G, Tuluc F, Starke K. Vasoconstrictor and vasodilator effects of guanine nucleotides in the rat aorta. Naunyn-Schmiedeberg’s Archives of Pharmacology 1997; 356: 653-661 PDF | Pubmed

Letters to the editor

  • Gunn AJ, Hoehn T, Hansmann G, Bührer C, Simbruner G, Gunn AJ, Yager J, Levene J, Hamrick SEG, Shankaran S, Thoresen M. Hypothermia: an evolving treatment for neonatal hypoxic ischemic encephalopathy. Pediatrics 2008; 121: 648-649 PDF | Pubmed
  • Sallmon H, Weber SC, von Gise A, Koehne P, Hansmann G. Ductal closure in neonates – a developmental perspective on platetet-endothelial interactions. Blood Coagulation and Fibrinolysis 2011; 22: 242-244 PDF | Pubmed
  • Hansmann G, Haas F, Sadiq M, Brook M, Gildein HP. Arrival and survival of a 3 week old boy from Pakistan with an arterial oxygen saturation of 17%. British Medical Journal 2009 [doi:10.1136/bcr.07.2008.0500] PDF | Pubmed